Whole Bone Matrix
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Whole Bone MatrixWhole Bone MatrixWhole Bone MatrixWhole Bone Matrix

Whole Bone Matrix

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Made using leg bones from 100% Australian Lake Eyre beef bones.  Selected bones are ground into bone chips approximately 10mm in size. Following this the bone chips are cleaned with a low temperature enzyme in water to remove any non-bone tissue and marrow fat. The cleaned bone chips are then vacuum dried over a 24 hour period to remove moisture and retain heat sensitive nutrients. Finally, the dried bone is milled into a fine powder for encapsulation.

Consuming grass-fed, whole bone matrix may nourish and support our own bone strength and remineralisation of teeth.  It provides bio-available calcium, phosphorous, type I collagen, glycosaminoglycans and bone stimulating peptides.

Nxgen's Whole Bone Matrix provides the calcium and phosphorous necessary for stronger bones, to help increase bone mass index, and to help avoid fractures and for improved dental health.  It is recommended to take it with Absolutely Pure Liver Capsules for Vitamin K2, to ensure the calcium is deposited in the bones where it is needed most. 

 

We Have Been Consuming Bones For Centuries

Bones were highly prized by traditional cultures across the globe. Since Paleolithic times indigenous tribes and our ancestors knew of 
the benefits of eating bones for their own health to build strong bones for themselves.  On continents far and wide, there's evidence of traditional cultures grinding up calcium-rich bones.  For the many cultures who did not have access to dairy food, bones were an alternative and bioavailable source of calcium.

Ancient indigenous tribes  didn't struggle with osteoporosis.  Broken bones and joint problems were uncommon. Their dental health was perfect (Weston Price).

In modern times, we have lost the traditional wisdom of our elders and our diets have altered, in some cases deteriorated, to solely plant-based and neglect the need for animal-based nutrients.

Our ancestors famously were renown hunter and gathers and ate nose to tail, honouring the whole animal and wasting nothing, bones included.  Skeletal bone is an organ, placing it in the same nutritional realm as liver, heart, brain, kidney, and sweetbreads.

Whole Bone has the ideal physiological ratio of calcium and phosphorus (2:1) in a microcrystalline structure that enhances absorption and bioavailability.   Unlike alternative synthetic calcium supplements whole bone is a source of naturally occurring growth factors and cytokines from a pure food source and contains type I collagen, essential trace minerals, and bone stimulating peptides (IGF I & II, TGF, β, osteocalcin) that nourish and support the  whole skeletal system for strength, flexibility, and remineralisation of our bones.

 

Bone Stimulating Peptides (IGF I & II, TGF β, Osteocalcin)

Peptides are tissue-specific information molecules, which influence gene expression.  They start the process of protein synthesis in cells, and regulate proper cellular function.  Our organs, including our bones, consistently produce peptides, but as we age and are impacted by a number of different stressors (environmental toxins, poor nutrition, emotional stress, etc.) our organs will naturally decrease protein synthesis and no longer be able to form new peptides at the same rate as during our youth. Deficiency of these nutrients results in cellular dysfunction, degenerative diseases, accelerated ageing, and bone loss.  One of the most effective ways to counter this deficiency is the consumption of bone specific peptides.

 

Ideal Ratio

Whole Bone contains calcium and phosphorus in the ideal physiological ratio of 2:1.  This harmonious ratio allows the body to retain its optimal mineral balance.  Supplementing with calcium alone can lead to mineral deficiencies and other health problems. The main function of phosphorous is for the formation of strong bones and teeth. It is also necessary for the body to synthesise protein  to support the growth, maintenance, and repair of cells and tissues. It even plays an important role in how the body uses carbohydrates and  fats and is needed for proper absorption of calcium. Calcium plays a key role for strengthening bones and teeth, regulating muscle function, blood clotting, the transmission of  nervous system messages, and enzyme function.

 

Backed By Science

For joint and bone health, it has been proven that daily oral ingestion of collagen decreases joint pain and increases bone mass density after 4-24 weeks (Moslowitz, 2000).  Castello-Branco et al carried out a clinical study and found microcrystalline hydroxyapatite MCHA from whole bone is considered to be more effective than calcium supplements in maintaining bone mass in post-menopausal women. In addition, they suggest it improves pain symptoms and accelerates fracture consolidation in patients with osteopenia or osteoporosis and is significantly more effective in preventing bone loss than calcium carbonate.

Another study found that hydroxyapatite improved cortical bone thickness in a group of women by 11.6 percent, compared to an improvement of only 7 percent with those who only supplemented with calcium gluconate.

Whole Bone contains approximately 20% by weight of organic matrix comprised primarily of collagen. Collagen is the major structural component of the bone matrix, whereby the majority is type I (approximately 90%) with smaller amounts of types III, V, X and XII.

Collagen gives bone its flexibility, whereas the addition of mineral to the collagen network provides bone with its stiffness. Without the addition of mineral to collagen, bone tissue would be very flexible, with properties similar to rubber.  Conversely without collagen, bone is brittle. Thus, varying the amounts and distribution of collagen and mineral provides bone with its ability to balance flexibility and stiffness requirements.

Alterations to the structure of collagen that occur from ageing or genetic abnormalities such as osteogenesis which can compromise the 
structural integrity of bone tissue and results in a weaker structure with a greater than normal susceptibility to fracture.

The remainder of the whole bone, approximately 70% by weight, serves as a reservoir for storing 99% of the body's total calcium,  approximately 85% of phosphorus and between 40 and 60% of the sodium and magnesium.  These mineral based ions form crystalline structures surrounding and within the collagen fibres to give bone its stiffness. Bone crystals are predominantly in the form of calcium hydroxyapatite   [Ca10PO4OH2], the primary mineral found in the skeleton.

 

 

 

 


 

 

 

 

REFERENCES

[1]  Ruegsegger. P, Keller. A, Dambacher. MA, (1995) Comparison of the treatment effects of ossein-hydroxyapatite compound and calcium carbonate in osteoporotic females

[2]  Galson. DL, et al (2011) Origins of Osteoblasts

[3]  Castelo-Branco. C, et al (2020) Efficacy and Safety of Ossein-Hydroxyapatite Complex verses Calcium Carbonate to Prevent Bone Loss

[4]  Epstein, O. Kato, Y. Dick, R. and Sherlock, S., (1982) Vitamin D, hydroxyapatite, and calcium gluconate in treatment of cortical bone thinning in postmenopausal women with primary biliary cirrhosis. The American Journal of Clinical Nutrition.

[5] Moskowitz, R.W., 2000. Role of collagen hydrolysate in bone and joint disease. Seminars Arthrit. Rheumat., 30: 87-99.

[6] Fuchs. RK et al (2009), Bone anatomy physiology and adaptation to mechanical loading.  Bone Repair Biomaterials

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